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Ascendis Pharma
NASDAQ: ASND Healthcare Pharma 🔎 Screen
🏹 Trader: 🚀 Stage 2 + Near High 📈 Stage 2 🎯 Near 52W High | BRS 85 Ready View all →
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$16.1B
Market Cap
P/E
PEG
-57.9%
ROCE
169.8%
ROE
-5.35
D/E
-18.9%
OPM
-4.9%
% from 52W High
81
α RS
🔍 ASND is showing a high-conviction setup because it matches 3 of 39 tracked screener presets, Sector RRG has Technology in the Leading quadrant with the trail still strengthening, and RS Rating is 81. Net: Broad signal stack, not a recommendation. ? Conviction RRG RS Rating
Sources
Conviction 3/39 · Technology in Leading quadrant · RS Rating 81
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🌏 Global Investor Returns
Currency-adjusted total returns for ASND including FX impact
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📈 Price History
Ratio Health
Excellent
Good
Average
Poor
By Category
📊 Sector Averages
About

Ascendis Pharma A/S, operates as a biopharmaceutical company that focuses on developing TransCon-based therapies for unmet medical needs in Europe, the United States, and internationally. The company offers SKYTROFA for treating pediatric patients with growth hormone deficiency; and YORVIPATH, a once-daily subcutaneous injection for the treatment of adults with chronic hypoparathyroidism. It is also developing a pipeline of three independent endocrinology rare disease product candidates in clinical development, as well as focuses on advancing oncology therapeutic candidates. The company was incorporated in 2006 and is based in Hellerup, Denmark.

Key Ratios Snapshot
📈 Growth Pattern
📊 Quick Scorecard
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⭐ Superinvestors Holding ASND
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Manager Shares Value % of Fund Period
Steve Cohen Point72 Asset Management 47.79M $70.5M 0.09% Mar 2026
Jim Simons Renaissance Technologies LLC 117.3K $26.8M 0.04% Mar 2026

SEC Form 13F data. 45-day lag from quarter end.

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📊 MIXED Ascendis Pharma reports EUR 247M revenue, profitable Q1 with three approved TransCon products
Revenue & Profitability
Total Q1 2026 revenue was EUR 247 million, including EUR 6 million in collaboration revenue. Operating profit was EUR 25 million (10% operating margin); non-IFRS operating profit was EUR 55 million (22% margin). Net profit reached EUR 629 million, boosted by a EUR 679 million deferred tax asset recognition. Non-IFRS net profit was EUR 18 million (EUR 0.27 per share). Cash and equivalents stood at EUR 573 million.
Outlook
Management expressed confidence in sustained revenue growth, citing strong underlying demand for YORVIPATH and the early successful launch of YUVIWEL (prescribed to over 60 children in the first five weeks). They noted steady new patient enrollment for SKYTROFA and improving insurance approval rates. The company expects continued improvement in operating margins as revenue scales.
Growth Drivers
Key growth levers include: global expansion of YORVIPATH (doses up to 60 mcg, patients aged 12-18, and once-weekly formulation); YUVIWEL label expansion (infants under 2 years, hypochondroplasia, and geographic expansion); SKYTROFA label expansion (doubling addressable U.S. population); and the combination therapy of TransCon CNP plus TransCon hGH for achondroplasia, which showed superior efficacy in the COACH trial.
Balance Sheet & CapEx
Not discussed in this earnings call.
Margins
Operating profit margin was 10% on a reported basis and 22% on a non-IFRS basis in Q1 2026. Management expects meaningful improvement in operating margin as revenue scales, with visibility over the course of 2026 and beyond.
Key Risks
Key risks highlighted include: ongoing IP litigation for YUVIWEL in the U.S. (ITC case), which management is confident will be resolved favorably; one-time revenue impacts from free drug programs and European market access adjustments (EUR 15 million combined in Q1); and potential reimbursement disruptions. Management also noted reliance on steady patient enrollment and approval rates.
Generated by AI · Q1 2026 results · Not investment advice
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✓ 📞 Earnings Call Transcripts (5 quarters) submit a missing quarter
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📞 Earnings Call Transcripts (5)
Q1 2026 Q1 2026 2026-05-07
Q1 2026 saw rapid revenue growth and profitability, driven by the FDA approval of YUVIWEL and strong uptake of YORVIPATH and SKYTROFA. Total revenue reached EUR 247 million, with robust patient and prescriber growth, and a strengthened balance sheet through asset sales and debt redemption.
Q4 2025 Q4 2025 2026-02-11
Strong revenue growth in 2025 driven by YORVIPATH and SKYTROFA, with expanding global launches and robust pipeline progress. Guidance targets EUR 500 million operating cash flow in 2026 and EUR 5 billion annual revenue by 2030, supported by a solid cash position and ongoing label expansions.
Q3 2025 Q3 2025 2025-11-12
Q3 2025 saw strong global growth for Yorvipath and SKYTROFA, with Yorvipath revenue at EUR 143 million and over 4,250 U.S. patients. Operating profit turned positive, and cash reserves increased to EUR 539 million. Continued revenue growth is expected, driven by new launches and label expansions.
Q2 2025 Q2 2025 2025-08-07
Q2 2025 saw strong revenue growth, led by YORVIPATH's global launch and SKYTROFA's label expansion. The company expects to achieve cash flow positivity this year, with continued momentum from new approvals and robust uptake across key products.
Q1 2025 Q1 2025 2025-05-01
Yorvipath's US launch drove a major revenue increase and high patient uptake, while Skytrofa maintained strong market share and stable pricing. Substantial revenue growth is expected in 2025, with continued expansion and positive clinical progress across the portfolio.
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📊 Analysis Methodology

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Financial Model
Projections are built from each company's audited annual financials (Income Statement, Balance Sheet, Cash Flow) over the last 5 fiscal years. Forward assumptions — revenue growth %, EBITDA margin, D&A (USD millions), interest expense, tax rate, and capex — are AI-generated using historical context and refreshed twice a year: after the December results season and after the September/Q4 results season.

DCF Valuation
Fair Value = Σ(FCFt / (1+WACC)t) + Terminal Value. Terminal Value uses the Gordon Growth Model: FCF5 × (1+g) / (WACC−g). Default WACC: 10% (US risk-free ~4.5%, equity risk premium ~5.5%). Default terminal growth: 3% (long-run US nominal GDP proxy).

CAGR Tracker
Expected 5-year CAGR = (DCF Fair Value / Current Price)1/5 − 1. Assumes fair value is reached in exactly 5 years — a mechanical estimate only.

Data Sources & Limitations
Financial statements sourced from public filings. Prices updated daily. Forward assumptions are AI-generated. All monetary values in USD millions. Non-US ADR companies may have currency conversion inaccuracies. Models are point-in-time and do not update intra-quarter or account for M&A, macro shocks, or extraordinary items.

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Investment Risk:
Investing in securities, including US equities and ETFs, involves inherent risks including the potential loss of principal. All investments are subject to market fluctuations, economic conditions, regulatory changes, and other factors that may affect their value. Past performance is not indicative of future results. This analysis is provided for informational and educational purposes only and should not be construed as investment advice under any circumstances.

No Investment Recommendation:
This analysis does not constitute, nor should it be interpreted as, an offer, solicitation, or recommendation to buy, sell, or hold any securities or financial products. Investors are strongly advised to conduct their own independent research and due diligence and to consult with a licensed financial advisor or an SEC-registered investment adviser before making any investment decisions, taking into account their individual financial situation, risk tolerance, and investment objectives.

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Conflict of Interest Disclosure:
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Information Sources:
The analysis is based on publicly available information including SEC filings (10-K, 10-Q), annual reports, management commentary, and publicly available financial data. Information is believed to be accurate as of the date of publication but may be subject to change without notice. Readers are encouraged to independently verify all information before acting upon it.

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