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Castle Biosciences, Inc.
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$938M
Market Cap
43.0
P/E
PEG
-11.4%
ROCE
-5.2%
ROE
0.08
D/E
-6.6%
OPM
-24.9%
% from 52W High
94
α RS
🔍 CSTL is showing a high-conviction setup because it matches 3 of 39 tracked screener presets, RS Rating is 94 (top decile vs market), and it's hugging the 21 EMA. Net: Broad signal stack, not a recommendation. ? Conviction RS Rating Technicals
Sources
Conviction 3/39 · RS Rating 94 · hugging 21 EMA
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🌏 Global Investor Returns
Currency-adjusted total returns for CSTL including FX impact
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📈 Price History
Ratio Health
Excellent
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Average
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By Category
📊 Sector Averages
About

Castle Biosciences, Inc., a molecular diagnostics company, provides test solutions for the diagnosis and treatment of dermatologic cancers, Barrett’s esophagus (BE), atopic dermatitis (AD), and uveal melanoma. The company offers DecisionDx-Melanoma, a risk stratification gene expression profile (GEP) test that predicts the likelihood of a positive sentinel lymph node and the risk of metastasis for patients with invasive cutaneous melanoma; TissueCypher, a risk stratification spatialomics test to predict future development of high-grade dysplasia and/or esophageal cancer in patients with non-dysplastic, indefinite dysplasia, and low-grade dysplasia BE; AdvanceAD-Tx, a non-invasive GEP test which is designed to guide systemic treatment selection for patients aged 12 years and older with moderateto-severe AD; DecisionDx-SCC, a GEP test for cutaneous squamous cell carcinoma; and MyPath Melanoma, a diagnostic GEP test for use in patients with difficult-to-diagnose melanocytic lesions. It also provides DecisionDx-UM, a risk stratification GEP test that predicts the risk of metastasis for patients with uveal melanoma. The company offers its products to dermatology and gastroenterology markets. The company was incorporated in 2007 and is headquartered in Friendswood, Texas.

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📈 Growth Pattern
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⭐ Superinvestors Holding CSTL
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Manager Shares Value % of Fund Period
Jim Simons Renaissance Technologies LLC 532.8K $13.1M 0.02% Mar 2026

SEC Form 13F data. 45-day lag from quarter end.

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✓ 📞 Earnings Call Transcripts (5 quarters) submit a missing quarter
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📞 Earnings Call Transcripts (5)
Q2 2026 Q2 2026 2026-07-30
Q2 2026 revenue grew 20% year-over-year to $103.5 million, driven by strong test volume growth in core products. Full-year revenue guidance was raised to $365–$375 million, with positive adjusted EBITDA expected for 2026. Robust cash reserves support ongoing investments in growth and pipeline expansion.
Q1 2026 Q1 2026 2026-05-06
Q1 2026 saw strong revenue and test volume growth, with record months for core products and improved margins. Full-year guidance was raised, and new clinical data reinforced product value. Reimbursement clarity for AdvanceAD-Tx is expected by Q3, with material revenue anticipated in 2027–2028.
Q4 2025 Q4 2025 2026-02-26
Delivered strong 2025 results with $344.2M revenue and robust test volume growth, especially for TissueCypher and DecisionDx-Melanoma. 2026 guidance projects continued core growth, with new product launches and pipeline investments supporting long-term expansion.
Q3 2025 Q3 2025 2025-11-03
Q3 2025 saw strong revenue growth, record test volumes, and the launch of AdvanceAD-Tx for atopic dermatitis. Guidance for 2025 revenue was raised, with continued momentum in core dermatology and GI franchises, though margins declined year-over-year.
Q2 2025 Q2 2025 2025-08-04
Q2 2025 saw $86.2M in revenue, strong test volume growth, and robust cash reserves. Guidance for 2025 revenue was raised to $310–$320M, with high single-digit volume growth expected for DecisionDx-Melanoma. Key risks include reimbursement changes and payer resistance.
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📊 Analysis Methodology

This comprehensive investment analysis was conducted using The Finmagine™ Stock Analysis & Ranking Methodology, a proprietary framework that systematically evaluates stocks across five critical dimensions: Financial Health, Growth Prospects, Competitive Positioning, Management Quality, and Valuation.

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Financial Model
Projections are built from each company's audited annual financials (Income Statement, Balance Sheet, Cash Flow) over the last 5 fiscal years. Forward assumptions — revenue growth %, EBITDA margin, D&A (USD millions), interest expense, tax rate, and capex — are AI-generated using historical context and refreshed twice a year: after the December results season and after the September/Q4 results season.

DCF Valuation
Fair Value = Σ(FCFt / (1+WACC)t) + Terminal Value. Terminal Value uses the Gordon Growth Model: FCF5 × (1+g) / (WACC−g). Default WACC: 10% (US risk-free ~4.5%, equity risk premium ~5.5%). Default terminal growth: 3% (long-run US nominal GDP proxy).

CAGR Tracker
Expected 5-year CAGR = (DCF Fair Value / Current Price)1/5 − 1. Assumes fair value is reached in exactly 5 years — a mechanical estimate only.

Data Sources & Limitations
Financial statements sourced from public filings. Prices updated daily. Forward assumptions are AI-generated. All monetary values in USD millions. Non-US ADR companies may have currency conversion inaccuracies. Models are point-in-time and do not update intra-quarter or account for M&A, macro shocks, or extraordinary items.

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Information Sources:
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