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OPKO Health, Inc.
$1.1B
Market Cap
79.0
P/E
55.80
PEG
-16.0%
ROCE
-17.1%
ROE
0.31
D/E
-36.1%
OPM
-7.1%
% from 52W High
67
α RS
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🌏 Global Investor Returns
Currency-adjusted total returns for OPK including FX impact
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About

OPKO Health, Inc. operates as a healthcare company, in the United States, Ireland, Chile, Spain, Israel, Mexico, and internationally. The company operates in two segments, Pharmaceutical and Diagnostics. The Pharmaceutical segment develops MDX2001, a tetra-specific antibody targeting several types of solid tumors in Phase 1 clinical trials; MDX2003, a tetra-specific antibody targeting two antigens for hematological tumors in Phase 1 clinical trials; and MDX2004, a trispecific immune modulator to rebuild and sustain the patient's own immune system. This segment also engages in the development of Epstein Barr Virus vaccine; Rayaldee, a patented extended-release product for oral administration containing 30 mcg of a prohormone; OPK-88006 oral and injectable product to regulate blood glucose and reduce body weight; NGENLA, recombinant human growth hormone product developed for the long-term treatment of pediatric patients with growth hormone deficiency. The Diagnostics segment offers laboratory testing services, such as detection, diagnosis, evaluation, monitoring, and treatment of diseases, as well as esoteric testing, molecular diagnostics, anatomical pathology, genetics, women’s health, and correctional healthcare under the BioReference brand; and 4Kscore test. OPKO Health, Inc. was founded in 2006 and is headquartered in Miami, Florida.

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⭐ Superinvestors Holding OPK
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Manager Shares Value % of Fund Period
Jim Simons Renaissance Technologies LLC 109.5K $125K 0.00% Mar 2026
Steve Cohen Point72 Asset Management 93.3K $106K 0.00% Mar 2026

SEC Form 13F data. 45-day lag from quarter end.

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✓ 📞 Earnings Call Transcripts (5 quarters) submit a missing quarter
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📞 Earnings Call Transcripts (5)
Q2 2026 Q2 2026 2026-07-27
Q2 2026 saw improved profitability, strong cash reserves, and pipeline progress, with revenue rising to $163.6M and operating loss narrowing to $7M. Diagnostics and pharma segments both improved, while guidance for 2026 was raised on the back of robust product and partnership revenue.
Q1 2026 Q1 2026 2026-04-28
Q1 2026 saw progress in clinical pipeline, improved operating losses, and strong cash reserves. Diagnostics and pharma segments showed sequential and year-over-year improvements, with guidance reaffirmed for 2026. Partnerships and streamlined operations support future growth.
Q4 2025 Q4 2025 2026-02-26
Exited 2025 with strong cash, streamlined diagnostics, and advancing ModeX pipeline. Q4 revenue declined year-over-year due to asset sales, but 4Kscore and international pharma showed growth. 2026 guidance anticipates revenue of $530–$560 million and increased R&D investment.
Q3 2025 Q3 2025 2025-10-29
Q3 2025 saw strong execution on strategic priorities, including the sale of oncology assets, robust cash position, and significant progress in diagnostics and therapeutics. BioReference and pharmaceutical segments both improved profitability, with 4Kscore test volumes up 20% and new partnerships fueling pipeline growth.
Q2 2025 Q2 2025 2025-07-31
Q2 2025 saw improved operating losses and strong progress in streamlining diagnostics, with the pending oncology asset sale to Labcorp expected to boost profitability. Pharmaceutical R&D advanced, supported by BARDA funding and strategic partnerships, while a robust cash position and share repurchase program underpin capital allocation.
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📊 Analysis Methodology

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Financial Model
Projections are built from each company's audited annual financials (Income Statement, Balance Sheet, Cash Flow) over the last 5 fiscal years. Forward assumptions — revenue growth %, EBITDA margin, D&A (USD millions), interest expense, tax rate, and capex — are AI-generated using historical context and refreshed twice a year: after the December results season and after the September/Q4 results season.

DCF Valuation
Fair Value = Σ(FCFt / (1+WACC)t) + Terminal Value. Terminal Value uses the Gordon Growth Model: FCF5 × (1+g) / (WACC−g). Default WACC: 10% (US risk-free ~4.5%, equity risk premium ~5.5%). Default terminal growth: 3% (long-run US nominal GDP proxy).

CAGR Tracker
Expected 5-year CAGR = (DCF Fair Value / Current Price)1/5 − 1. Assumes fair value is reached in exactly 5 years — a mechanical estimate only.

Data Sources & Limitations
Financial statements sourced from public filings. Prices updated daily. Forward assumptions are AI-generated. All monetary values in USD millions. Non-US ADR companies may have currency conversion inaccuracies. Models are point-in-time and do not update intra-quarter or account for M&A, macro shocks, or extraordinary items.

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Investment Risk:
Investing in securities, including US equities and ETFs, involves inherent risks including the potential loss of principal. All investments are subject to market fluctuations, economic conditions, regulatory changes, and other factors that may affect their value. Past performance is not indicative of future results. This analysis is provided for informational and educational purposes only and should not be construed as investment advice under any circumstances.

No Investment Recommendation:
This analysis does not constitute, nor should it be interpreted as, an offer, solicitation, or recommendation to buy, sell, or hold any securities or financial products. Investors are strongly advised to conduct their own independent research and due diligence and to consult with a licensed financial advisor or an SEC-registered investment adviser before making any investment decisions, taking into account their individual financial situation, risk tolerance, and investment objectives.

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Conflict of Interest Disclosure:
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Information Sources:
The analysis is based on publicly available information including SEC filings (10-K, 10-Q), annual reports, management commentary, and publicly available financial data. Information is believed to be accurate as of the date of publication but may be subject to change without notice. Readers are encouraged to independently verify all information before acting upon it.

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